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MESO BOTO-X treme+ (Targeted and effective alternative to Botulinum) (10 ml)

MESO BOTO-X treme+ (Targeted and effective alternative to Botulinum) (10 ml)

(Also for non‑invasive treatment, e.g., with MESOpower Pen.)

See the tabs for a detailed description of: Ingredients, Treatment areas, Results, Treatment protocol

1 set includes

  • 1 × MESO BOTO‑Xtreme+ (10 ml sterile, approx. 10–20 treatments) 
  • 10 × sterile syringes (For withdrawing product from the sterile vial using the non‑invasive method.)
  • 10 × sterile hypodermic needles (For withdrawing product from the sterile vial using the non‑invasive method.)

Facts

  • Active ingredients: penta‑, hexa‑ and octa‑peptides, as well as Avena sativa and hyaluronic acid (HA)
  • Indication: anti‑aging
  • Result: botulinum‑like (Botox‑like) effect
  • Efficacy‑driving ingredients: multi‑peptides
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Stock status: In stock
Model/Product no.: MST406

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We ship WorldWide every day

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Customer service and support

Call us at
(+45) 71741108

Certified products

Produced in the EU

MESO BOTO‑XTREME+

TARGETED, RESULTS‑DRIVEN ALTERNATIVE TO BOTULINUM
Professional meso‑cocktail for visible smoothing, firming and hydration of the face and neck.
See the buttons above for detailed information about: Ingredients, Treatment areas and results, Usage guide, Downloads.

The treatment helps

  • Reduces under‑eye wrinkles and fine lines.
  • Firms and lifts visibly lax skin.
  • Softens neck folds and double‑chin‑related laxity.
  • General skin renewal – intense hydration, elasticity and vitality.
  • Delivers a smoother, more elastic, youthful look.

Treatment areas

  • Face
  • Neck and double chin

Recommended course

  • Month 1–2: 1 treatment weekly (total 4–8).
  • Month 3: 1 treatment every other week (total 2).
  • Maintenance: 1 treatment every 3 months.

Active ingredients

  • Acetyl Hexapeptide‑8 (Argireline®)
  • Acetyl Octapeptide‑3 (SNAP‑8®)
  • Pentapeptide‑3 (Leuphasyl®)
  • Sodium Hyaluronate (hyaluronic acid)
  • Retinol & Ascorbic Acid (Vitamin C)
  • Avena Sativa Extract (beta‑glucan, avenanthramides)
  • Zinc/Copper/Cobalt (mineral support)
  • Arginine Aspartate, Valine, Pyridoxine, Thiamine HCl
  • Regulators: Sodium Chloride, Sodium Hydroxide

MESO BOTO‑Xtreme+ Professional mesotherapy for firming and wrinkle reduction

Who can perform the treatment

MESO BOTO‑Xtreme+ is an advanced mesotherapy treatment that restructures and firms the skin. It works in depth to restore a youthful appearance with a unique combination of active ingredients.

 

Treatment with MESO BOTO‑XTREME+ is not physician‑only when performed using a non‑invasive method.

 

It can be performed with, e.g., the MESOpower Pen together with the MESO 11‑Point Micro Module and MESO 3‑Point Nano Module by qualified practitioners (cosmetologists, meso‑ and PMU artists, etc.).

Mechanism – how the product works

MESO BOTO‑XTREME+ is a firming, restructuring meso‑cocktail that works from within to restore the skin’s firmness and smoothness. A combination of biomimetic peptides (Argireline®, SNAP‑8®, Leuphasyl®), hyaluronic acid and retinol/Vitamin C smooths fine lines and strengthens the skin structure.

Reduce wrinkles under the eyes

The synergy of peptides and actives reduces under‑eye wrinkles, softens neck folds and improves elasticity and moisture.

Target the first signs of ageing

Actives with documented effects address the primary causes of early signs of ageing – without using botulinum toxin.

How the treatment works

 

Muscle tone is regulated by the neurotransmitter acetylcholine, which is released via the SNARE protein complex consisting of VAMP, Syntaxin and SNAP‑25.

 

  1. Under normal conditions, a “protein hinge” forms between the vesicle and cell membrane, releasing acetylcholine into the synapse and triggering muscle contraction.
  2. Botulinum toxin acts irreversibly by destroying the SNARE complex so vesicles cannot release acetylcholine. The result is full blockade – but also side effects.
  3. MESO BOTO‑Xtreme+ works differently: the biomimetic peptides only slightly destabilize SNAP‑25. The SNARE complex is weakened and muscles relax – without completely blocking neurotransmission.
The result is:

  • Controlled muscle relaxation.

  • Prevention and smoothing of wrinkles.

  • Preservation of the skin’s natural functions.

Additional effects

  • Intense revitalization and hydration of tired or lax skin.

  • Reduces visible signs of ageing and delivers a smooth, elastic skin appearance.

  • Provides nutrients that strengthen vitality and barrier function.

MESO BOTO‑XTREME+ – product
Before/after – male

 

As effective as botulinum – without side effects

  • The same relaxing and smoothing action as botulinum, but without irreversible damage.

  • Muscles retain neurotransmission capability, delivering natural, safe outcomes.

  • The treatment combines firming, hydration, nourishment and antioxidant protection.

  • Up to 63% less wrinkle depth and visible improvement of the skin’s appearance are reported in related literature. Avena sativa (beta‑glucan) binds water, protects against irritants and forms a light film, leaving skin soft and smooth. Beta‑glucan may inhibit xanthine oxidase and reduce free radicals; avenanthramides show a soothing effect on UV‑exposed skin.

Clinical benefits

  • Revitalizes and hydrates tired or stressed skin.

  • Treats and smooths fine lines and wrinkles.

  • Targets the primary causes of early ageing signs with documented clinical effect.

  • Restores density and firmness in mature or lax skin.

  • Reduces under‑eye wrinkles and neck folds.

  • Leaves the skin looking firm, elastic and healthy.

Clinical use

Indications
Suitable for early to moderate dynamic lines in:
  • Forehead – smooths horizontal lines.
  • Glabella – reduces vertical “frown lines”.
  • Periorbital areas – softens fine lines and crow’s feet.
Use
  • May be used as a pre‑event course for a visible, natural lift.
  • Effective for maintenance between other anti‑age procedures.
Combination
Can advantageously be combined with:
  • Gentle peel for improved permeation and renewal.
  • LED therapy for added glow and comfort.
Skin types
Compatible with most skin types – including sensitive skin when proper barrier care and hygiene are ensured.

Expected clinical goals

  • Immediate softening and smoothing of fine lines.
  • Improved surface appearance after the first treatment.
  • Progressive improvements in elasticity, firmness and texture within 2–6 weeks.
  • High client satisfaction with a natural, relaxed (non‑“frozen”) look.
     
Clinical benefits
  • Revitalizes and deeply hydrates tired or stressed skin.
  • Treats and reduces fine lines and wrinkles.
  • Targets the primary causes of early ageing with documented clinical results.
  • Restores density and firmness in mature or lax skin.
  • Effectively reduces under‑eye wrinkles and smooths neck folds.
  • Leaves the skin stronger, elastic and healthy with a visibly younger look.
Product – Meso BOTO‑XTREME+
Before/after – male
Product – BOTO‑XTREME+ (pack)
Before/after – male (graph placeholder)

Treatment results

  • Visibly smoother eye area and fine lines.
  • Less laxity and clearer contours in the face and neck.
  • Improved skin quality: moisture, elasticity and comfort.
  • Fast cosmetic effect with a professional finish.

Overall effect of the treatment

  • Alternative to botulinum without toxin‑related side effects.
  • Peptide‑driven relaxation + skin‑building actives.
  • Fits seamlessly into the clinic’s anti‑age portfolio and treatment courses.

Ingredients (INCI code)

Mesoskinline’s meso‑cocktails are ready to use

  • No mixing or preparation required. Dermatologically tested. Tested for non‑invasive mesotherapy.

Mesoskinline meso‑cocktails comply with the CIA standards.

  • Mesoskinline cocktails represent the very best in anti‑age products with an advanced formulation of active ingredients and antioxidants.

 

  • The carefully selected components with low molecular weight ensure deep penetration and an intensive effect, resulting in optimal distribution and activity in the skin layers.

 

  • This is achieved without the negative side effects seen in less concentrated products with higher molecular weight.

 

Compliance with the CIA parameters

  • guarantees the highest quality results and quick, convincing effects.

All our meso‑cocktails contain

  • Key ingredient – for an immediate result.
  • Antioxidant ingredient – balances free radicals after dermatological treatment.
  • Synergy – focused on preventing and correcting beauty concerns.

Ingredients and action

Aqua (Water)
Base of the formulation and solvent for the actives. Contributes to hydration.

Retinol (Vitamin A)
Stimulates cell renewal, reduces fine lines and pigmentation, improves texture and gives a more even appearance.

Ascorbic Acid (Vitamin C)
Antioxidant; protects against free radicals, brightens skin tone, stimulates collagen and reduces signs of ageing.

Argireline® (Acetyl Hexapeptide‑8)
Botox‑like peptide; reduces muscle contractions and diminishes expression lines and wrinkles.

SNAP‑8® (Acetyl Octapeptide‑3)
Reduces muscle activity, smooths wrinkles and supports firmness and elasticity.

Leuphasyl® (Pentapeptide‑3)
Complements Argireline® and SNAP‑8® by further relaxing expression muscles, reducing lines and improving elasticity.

Sodium Hyaluronate (Hyaluronic Acid)
Binds and retains moisture, plumps lines from within and leaves a smooth, youthful surface.

Avena Sativa Extract (Oat)
Soothes skin, reduces irritation and redness; anti‑inflammatory.

Zinc Chloride
Regulates sebum, helps prevent clogged pores, strengthens the barrier and protects against environmental stressors.

Copper Gluconate
Promotes collagen production; antioxidant; protects against signs of ageing.

Cobalt Gluconate
Boosts cellular energy and metabolism for a more vital, radiant look.

Arginine Aspartate
Supports regeneration, moisture balance and elasticity.

Valine
Essential amino acid that promotes tissue repair and strengthens structure.

Pyridoxine (Vitamin B6)
Regulates sebum, soothes irritation, reduces acne and supports a healthy skin state.

Thiamine HCl (Vitamin B1)
Antioxidant that protects against oxidative stress, supports repair and counters early ageing.

Sodium Chloride
Stabilizes viscosity and improves formulation longevity.

Sodium Hydroxide
Adjusts pH for optimal tolerance.

Active ingredients and effects
 

Acetyl Hexapeptide‑8 (Argireline®)
Botox‑like peptide; reduces muscle contractions, diminishing expression lines and wrinkles.

Acetyl Octapeptide‑3 (SNAP‑8®)
Decreases muscle activity, smooths wrinkles and supports firmness and elasticity.

Pentapeptide‑3 (Leuphasyl®)
Relaxes expression muscles; complements Argireline® and SNAP‑8® for further line reduction and improved elasticity.

Sodium Hyaluronate (Hyaluronic Acid)
Binds/retains moisture, fills fine lines and delivers a smooth, youthful look.

Retinol & Ascorbic Acid (Vitamin C)
Stimulates renewal, reduces pigmentation, improves texture, protects vs. free radicals and supports collagen.

Avena Sativa Extract (Beta‑glucan, avenanthramides)
Soothes skin, reduces irritation/redness, anti‑inflammatory and supports comfort.

Zinc / Copper / Cobalt (Mineral support)
Balances sebum; supports collagen and energy metabolism; protects against oxidative stress and environmental damage.

Arginine Aspartate, Valine, Pyridoxine, Thiamine HCl
Amino acids and B‑vitamins for regeneration, moisture balance, tissue repair and natural defenses.

Regulators: Sodium Chloride, Sodium Hydroxide
Stabilize the formula, adjust pH and ensure tolerance.

Overall effect

This professional meso‑cocktail combines biomimetic peptides (Argireline®, SNAP‑8®, Leuphasyl®) with hyaluronic acid, vitamins, minerals, amino acids and antioxidants.

The effects are:

  • Targeted, gentle reduction of expression lines and wrinkles.

  • Intense hydration and restoration of skin density.

  • Visible improvements in elasticity, firmness and comfort.

  • Effective protection against oxidative stress and environmental impact.

  • A smoother, more youthful and vital skin texture.

 

Ingredients 409
Treatment Areas and Results 410
How to use 411

Ingredients and their Functions:

Aqua (Water)

  • Origin: Purified water.
  • Effect: The base of the product, serving as a solvent for active ingredients. Contributes to hydration.

Retinol (Vitamin A)

  • Origin: Synthetic or derived from natural sources such as fish or plants.
  • Effect:
    • Promotes cell renewal, resulting in smoother and more even skin.
    • Reduces the appearance of fine lines and wrinkles.
    • Improves skin texture and reduces pigmentation.

Ascorbic Acid (Vitamin C)

  • Origin: Extracted from citrus fruits or produced synthetically.
  • Effect:
    • Powerful antioxidant that protects against free radicals.
    • Brightens the skin and improves skin tone.
    • Stimulates collagen production and reduces signs of aging.

Pentapeptide-3

  • Origin: Synthetic peptide.
  • Effect:
    • Improves skin firmness and elasticity.
    • Enhances collagen synthesis and reduces wrinkles.

Acetyl Hexapeptide-8

  • Origin: Synthetically produced.
  • Effect:
    • Known as a “Botox-like” peptide.
    • Reduces muscle contractions, thereby diminishing fine lines and wrinkles.

Acetyl Octapeptide-3

  • Origin: Synthetic peptide.
  • Effect:
    • Reduces muscle activity and minimizes the appearance of wrinkles.
    • Supports skin firmness and elasticity.

Sodium Hyaluronate

  • Origin: Derived from hyaluronic acid through fermentation.
  • Effect:
    • Provides intense hydration by attracting moisture to the skin.
    • Plumps the skin, reducing fine lines and imparting a more youthful glow.

Avena Sativa Extract (Oat Extract)

  • Origin: Extracted from oat kernels.
  • Effect:
    • Soothes and calms the skin with anti-inflammatory properties.
    • Reduces irritation and redness.

Zinc Chloride

  • Origin: Chemically produced.
  • Effect:
    • Regulates sebum production and prevents clogged pores.
    • Strengthens the skin’s barrier and protects against environmental damage.

Copper Gluconate

  • Origin: Combination of copper and gluconic acid.
  • Effect:
    • Supports collagen synthesis.
    • Has antioxidant properties that protect the skin from aging.

Cobalt Gluconate

  • Origin: Combination of cobalt and gluconic acid.
  • Effect:
    • Boosts the skin’s energy and metabolism.
    • Contributes to a more radiant complexion.

Arginine Aspartate

  • Origin: Amino acids from plants or synthetically produced.
  • Effect:
    • Promotes skin regeneration and elasticity.
    • Contributes to skin hydration and cell renewal.

Valine

  • Origin: Essential amino acid found in protein-rich foods like beans and grains.
  • Effect:
    • Aids in tissue repair and strengthens the skin’s structure.

Pyridoxine (Vitamin B6)

  • Origin: Found in foods such as fish and bananas, or produced synthetically.
  • Effect:
    • Regulates sebum production and promotes healthy skin.
    • Soothes irritation and reduces acne.

Thiamine HCL (Vitamin B1)

  • Origin: Found in whole grains or synthetically produced.
  • Effect:
    • Protects against oxidative stress and prevents premature aging.
    • Supports the skin’s natural repair processes.

Sodium Chloride

  • Origin: Naturally occurring salt.
  • Effect:
    • Stabilizes the product’s viscosity.
    • Improves the formulation’s stability.

Sodium Hydroxide

  • Origin: Synthetically produced.
  • Effect:
    • Adjusts the pH level to ensure skin tolerance.

Anti-age Properties:
These ingredients work together to hydrate, stimulate collagen production, improve skin elasticity, and protect against oxidative stress, resulting in more youthful, firm, and radiant skin.

 

List of Active Ingredients with their Origin, Effect, and Anti-aging Properties:

Pentapeptides, Hexapeptides, and Octapeptides

  • Origin: Synthetically produced small chains of amino acids.
  • Effect:
    • Reduce fine lines and wrinkles by inhibiting muscle contractions.
    • Improve skin firmness and elasticity by stimulating collagen production.
    • Promote smoother, more youthful-looking skin.

EGF (Epidermal Growth Factor)

  • Origin: Biotechnologically produced protein that mimics the body’s own growth factors.
  • Effect:
    • Stimulates the growth and regeneration of skin cells by binding to epidermal growth factor receptors.
    • Improves cell renewal, healing, and strengthens the skin’s structure.
    • Reduces signs of aging and enhances the skin’s regenerative capacity.

Ferulic Acid

  • Origin: Naturally found in the cell walls of plants such as rice, wheat, and oats.
  • Effect:
    • Powerful antioxidant that protects the skin against oxidative stress and UV damage.
    • Reduces pigmentation and brightens the skin by inhibiting melanin production.

Ubiquinone (Coenzyme Q10)

  • Origin: Naturally occurring antioxidant in the body, also produced synthetically for cosmetics.
  • Effect:
    • Protects the skin from free radicals and environmental damage.
    • Improves the strength and elasticity of cell membranes.
    • Supports cell renewal and reduces visible signs of aging.

Sodium DNA

  • Origin: Extracted from natural sources, often fish DNA.
  • Effect:
    • Deeply moisturizes and promotes cell renewal.
    • Rebuilds connective tissue and strengthens the skin’s structure.
    • Effective for skin healing and regeneration, especially with technologies like mesopen and ultrasound.

Hyaluronic Acid (Sodium Hyaluronate)

  • Origin: Produced through biotechnology, often via bacterial fermentation.
  • Effect:
    • Binds water to the skin, providing intensive moisture.
    • Improves skin volume and elasticity, reducing wrinkles and fine lines.
    • Leaves the skin smooth, plump, and youthful.

Avena Sativa (Oat Extract)

  • Origin: Extracted from oat kernels.
  • Effect:
    • Soothes the skin and reduces inflammation.
    • Protects against environmental damage and strengthens the skin’s natural barrier.
    • Moisturizes and calms irritated skin.

Lecithin, Phytosterols, and Fatty Acids

  • Origin: Extracted from soybeans or sunflower seeds.
  • Effect:
    • Improves the skin’s barrier and reduces moisture loss.
    • Regenerates damaged tissue and strengthens skin elasticity.
    • Supports the skin’s structure, providing a softer, smoother surface.

Anti-aging Properties

These active ingredients work synergistically to:

  • Reduce wrinkles and improve skin elasticity.
  • Protect against free radicals and UV damage.
  • Improve cell renewal and regeneration.
  • Provide intense moisture and strengthen the skin’s barrier, resulting in firm, smooth, and youthful skin.

 

Overall Effect of the Formula

  • Promotes stem cell proliferation and regeneration of damaged tissue.
  • Reduces signs of aging such as wrinkles and fine lines.
  • Improves the skin’s moisture, texture, and appearance.
  • Strengthens the skin’s natural barrier and provides intensive hydration.

These ingredients work synergistically to provide healthy, youthful, and revitalized skin.

 

Treatment Areas and Results

Treatment Areas:

  • Face:

    • Reduces fine lines and wrinkles.
    • Improves skin firmness and elasticity.
    • Brightens the skin and minimizes pigmentation.

  • Neck:

    • Tightens the skin and reduces visible signs of aging.
    • Gives the skin a more youthful appearance.

  • Décolleté:

    • Enhances skin texture and hydration.
    • Strengthens the skin barrier and reduces dryness.

Results:

  1. Intensive Hydration:

    • Ingredients like Sodium DNA and hyaluronic acid bind moisture to the skin, leaving it smooth and hydrated.
    • Ceramides and squalane help strengthen the skin barrier and retain moisture.

  2. Reduced Aging:

    • EGF (Epidermal Growth Factor): Stimulates cell renewal and regenerates damaged tissue, reducing wrinkles and fine lines.
    • Ferulic Acid: Protects against UV damage and oxidative stress, which accelerates skin aging.

  3. Skin Tightening:

    • Promotes collagen production for firmer and more elastic skin.
    • Strengthens connective tissue and improves skin firmness.

  4. Improved Skin Texture:

    • Ubiquinone (Coenzyme Q10): Enhances elasticity and strengthens cell membranes, creating smoother, more even skin.
    • Brightens the skin by reducing melanin production and evening out pigmentation.

  5. Strengthened Skin Barrier:

    • Ingredients like lecithin, phytosterols, and shea butter help rebuild the skin’s natural protection.

  6. Regeneration of Damaged Tissue:

    • Sodium DNA: Repairs damaged skin cells and promotes healing, improving the skin’s overall health.

Recommendation:

For optimal penetration and maximum results, this treatment can be combined with technologies such as:

  • Electroporation
  • Ultrasound
  • Mesopen or Mesoroller

These technologies enhance the effectiveness of active ingredients by ensuring deeper penetration into the skin.

Step-by-Step Guide for MESO BOTO-Xtreme Treatment

STEP 1: Preparation with MESO PURE PEEL

  1. Prepare the skin thoroughly:

    • Cleanse the treatment area and remove any makeup.
    • Gently apply MESO PURE PEEL to the skin and massage lightly. Do not rinse off.

  2. Active ingredients in MESO PURE PEEL:

    • Lactic Acid, Citric Acid, Malic Acid: Exfoliate and improve skin texture.
    • Bisabolol: Soothes and calms the skin.
    • Citrus Grandis, Vaccinum Myrtillus, and Lemon Peel Extracts: Natural antioxidants that strengthen the skin.

STEP 2: Application of MESO BOTO-Xtreme with Microneedling Modules

  1. Choose the correct needle module:

    • 3-point needle module: For treating thin and visible lines. Work back and forth along the lines using the "press-and-lift" motion.
    • 11-point needle module: For areas with multiple small lines or crepey skin. Work directly on and between the lines using the "press-and-lift" motion.

  2. Settings:

    • Use speed 4-6 and full needle length until micro-bleeding occurs (indicating you are working in the dermis).

  3. Product application:

    • Hold the device in your dominant hand and a 1 ml syringe in the other.
    • Continuously apply small amounts of MESO BOTO-Xtreme during the procedure for optimal penetration.

STEP 3: MESO ANTI-AGE MASK

  1. Apply the mask:

    • Place the transdermal double-layer hydrogel mask on the treated area.

  2. Let the mask work:

    • Leave the mask on for 30 minutes for maximum anti-aging benefits.
    • The active ingredients penetrate deeply into the skin to enhance cell renewal.

  3. Tip:

    • Perform a light massage over the mask during the first 10-15 minutes to improve absorption.

STEP 4: Apply Spheracoll (Vegan Collagen)

  1. After the mask:

    • Remove the mask and evenly apply Spheracoll (1 ball + 2.5 ml activator) to the skin.
    • Massage thoroughly until the product is fully absorbed.

  2. Result:

    • Provides deep hydration, reduces redness, and integrates ingredients into the dermis.

STEP 5: Finish with MESO LIFT AND PROTECT (SPF 50+)

  1. Apply a thin layer:

    • Distribute MESO LIFT AND PROTECT over the treated areas.

  2. Protection:

    • The product offers sun protection and anti-aging benefits for up to 8 hours.
    • Ideal for daily use on dry, sensitive, or photosensitive skin.

Important Notes and Tips

  • Always use the "press-and-lift" technique during microneedling to avoid skin abrasion, scabbing, and hyperpigmentation.
  • Ensure the skin is not dry during the procedure – keep it hydrated with small doses of the product from the syringe.
  • Treatment areas: Forehead, eyes, cheeks, and neck (recommended dose is 0.5 ml per area).

Tip: If you see no redness after the treatment, you should work more intensively on this client next time.

Treatment Program

  1. 1st and 2nd Month:

    • 1 session per week – 4-8 sessions in total.

  2. 3rd Month:

    • 1 session every two weeks – 2 sessions in total.

  3. Follow-up:

    • 1 session every 3 months – recommended to maintain results.

WATCH THE INSTRUCTION VIDEO HERE

 

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